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目的:评价顺铂辅助化疗联合放射治疗晚期子宫颈癌的疗效。方法:同期对比分析经放疗加顺铂化疗(放化组)60例和单纯放疗(单放组)60例Ⅲ期子宫颈癌患者5年生存率、局部控制率、远处转移率和并发症。结果:5年生存率放化组63.33%,单放组43.33%(P<0.05)。局部控制率放化组80%,单放组60%(P<0.05)。远处转移率放化组43.33%,单放组41.66%(P>0.05)。放射性直肠炎:放化组13.33%,单放组10.00%(P>0.05)。放射性膀胱炎放化组8.33%,单放组10.00%(P>0.05)。无因治疗而引起的死亡发生。结论:放射治疗联合顺铂化疗能提高Ⅲ期子宫颈癌患者局部控制率和5年生存率,未改善远处转移率,副作用能耐受。
Objective: To evaluate the efficacy of cisplatin adjuvant chemotherapy combined with radiotherapy for advanced cervical cancer. Methods: The 5-year survival rate, local control rate, distant metastasis rate and complications of 60 patients with stage III cervical cancer treated with radiotherapy plus cisplatin chemotherapy (radiotherapy group) and 60 patients with radiotherapy alone (radiotherapy alone group) . Results: The 5-year survival rate was 63.33% in radiotherapy group and 43.33% in radiotherapy alone group (P <0.05). Local control rate of 80% radiotherapy group, radiotherapy alone group 60% (P <0.05). The distant metastasis rate was 43.33% in radiotherapy group and 41.66% in radiotherapy group (P> 0.05). Radiation proctitis: Radiotherapy group 13.33%, single group 10.00% (P> 0.05). Radioactive cystitis group 8.33%, single group 10.00% (P> 0.05). No cause of death caused by treatment. Conclusion: Radiotherapy combined with cisplatin chemotherapy can improve the local control rate and 5-year survival rate of stage Ⅲ cervical cancer patients without improving the distant metastasis rate and side effects.