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目的探讨血必净注射液对重症感染患者的抗炎作用。方法将确诊为脓重症感染的30例患者随机分成两组,对照组(n=15)患者给予抗生素、对症及常规营养支持治疗,如病情需要可给予脏器替代治疗,包括使用呼吸机和/或血液透析;血必净组(n=15)患者在对照组治疗的基础上加用血必净注射液100ml,静脉滴注,1次/12h,连用7d,对患者进行降钙素原(PCT)、C-反应蛋白(CRP)、WBC计数测定。结果治疗前后血必净组PCT、CRP、WBC计数水平间差别有显著性意义(p<0.05),治疗后与对照组间差别有显著性意义(p<0.05)。结论血必净注射液对炎症因子具有拮抗作用,可阻断全身炎症反应综合征(SIRS)的病理反应过程,改善重症感染患者的预后,减少住院时间。
Objective To investigate the anti-inflammatory effect of Xuebijing injection in patients with severe infection. Methods Thirty patients diagnosed as severe pus infection were randomly divided into two groups. Patients in the control group (n = 15) were given antibiotics, symptomatic and routine nutritional support. If necessary, organ replacement therapy could be given, including ventilator and / Or hemodialysis; Xuebijing group (n = 15) based on the treatment of patients in the control group plus Xuebijing injection 100ml, intravenous infusion, 1 / 12h, once every 7d, patients with procalcitonin PCT), C-reactive protein (CRP), WBC count determination. Results The levels of PCT, CRP and WBC in Xuebijing group before and after treatment were significantly different (p <0.05), and there was significant difference between the two groups after treatment (p <0.05). Conclusion Xuebijing Injection has an antagonistic effect on inflammatory factors, which can block the pathological reaction of systemic inflammatory response syndrome (SIRS), improve the prognosis of patients with severe infections and reduce the length of hospital stay.