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约99%的多发性骨髓瘤患者的血清和/或尿中有一种单克隆蛋白。这导致了一种普遍接受的概念,即骨髓瘤在细胞水平是一种单克隆疾病。然而这不过是一种推测。虽然骨髓瘤是来源于一株特异性基因型的克隆,但是在肿瘤的生长过程中可能发生突变产生新的克隆。这些克隆可以保持(亦可不保持)同一基因型。这种克隆异质性(即多克隆性)对于生物学研究和临床处理有重要意义。
About 99% of patients with multiple myeloma have a monoclonal protein in the serum and / or urine. This led to the generally accepted notion that myeloma is a monoclonal disease at the cellular level. However, this is only a guess. Although myeloma is a clone derived from a specific genotype, mutations may occur during tumor growth to produce new clones. These clones may or may not maintain the same genotype. This clonal heterogeneity (ie, polyclonal) is of great importance for biological research and clinical management.