Correlation of the Appearances of DSA with VEGF Expression and Its Clinical Significance in Patients

• 作 者: CHEN Fangman JIAO Xudong DU Fang
• 机 构: Department of Radiology
• 出 处: 中德临床肿瘤学杂志（英文版）
• 发表日期: 2004年期
• 关键词: hepatocellular carcinoma (HCC) digital subtraction angiography (DSA) Vascular En

Objective: To investigate the relationship between the appearances of digital subtraction angiography (DSA) and the serum level of vascular endothelial growth factor (VEGF) in patients with primary hepatocellular carcinoma (HCC). Methods: 24 HCC patients, 30 times DSA were examined, serum VEGF level was measured with the quantitative enzyme linked immunosorbent assay (ELISA) in patients and healthy control subjects in this study. Results: Among DSA for 24 patients with HCC, 18 of 24 cases showed hepatic artery blood supply of tumor. Four of 24 cases showed portal vein blood supply of tumor,1 of 24 cases showed superior mesenteric artery blood supply of tumor and artery-venous shunt formation, and there was no blood supply to tumor in one case. Serum VEGF level in HCC[(χ+s)194.5±14.2] ng/L was significant elevated to those in patients comparing with those of the normal controls (132.4±47.9)ng/L and marked differences (P＜0.01). Conclusion: During the cases for plenty blood supply or arteryvenous shunt formation in patients with HCC, serum VEGF level markedly elevated in the patients of HCC. VEGF expression was significantly related to intrahepatic dissemination, recurrence and metastasis in patients with HCC.