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为研究充血性心力衰竭治疗前后心房利钠肽浓度的变化,作者观察了5例男性和10例女性患者,年龄38-75岁(63±15)。心衰程度:Ⅳ级7例、Ⅲ级5例、Ⅱ级3例。病因:冠心病8例、心脏瓣膜病2例、高心病2例、房间隔缺损2例、扩张型心肌病1例。血浆心房利钠肽浓度(放免法测定)在入院时都非常高,达251.4±64.7皮克/毫升(MISEM),正常为31.7±12.0皮克/毫升,n=124。经治疗心衰症状缓解后,所有患者心房利钠肽水平皆下降,达92.5±29.4皮克/毫升(P<0.005)。这可能是由于左室容量超负荷减少所致。另Singer等报告1例56岁男性患者,心衰恶化
To study changes in atrial natriuretic peptide concentrations before and after treatment of congestive heart failure, the authors observed 5 males and 10 females aged 38-75 years (63 ± 15 years). Heart failure: grade Ⅳ in 7 cases, grade Ⅲ in 5 cases, grade Ⅱ in 3 cases. Etiology: 8 cases of coronary heart disease, valvular heart disease in 2 cases, 2 cases of heart disease, atrial septal defect in 2 cases, 1 case of dilated cardiomyopathy. Plasma atrial natriuretic peptide concentrations (radioimmunoassay) were very high at admission, reaching 251.4 ± 64.7 pg / ml (MISEM), normalized to 31.7 ± 12.0 pg / ml, n = 124. After treatment of symptomatic relief of heart failure, all patients had atrial natriuretic peptide levels decreased to 92.5 ± 29.4 pg / ml (P <0.005). This may be due to reduced left ventricular volume overload. Another Singer et al reported a 56-year-old male patient with worsening heart failure