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目的 探讨我国汉族人结核病易感性或抗性与HLA—I类抗原的关系。方法 应用HLA—A、B、C血清,对东北地区100例结核病患者和101例健康人做HLA—I类抗原分型。结果 TB组HLA—A31、A27、A35出现的频率,相对风险率(RR)分别为-9.92,3.6,25,其他等位基因在正常人和结核病人中的分布无明显差异。提示 HLA-B27,B35,尤其B35可能就是我国汉族人结核病的易感基因之一,HLA—A31可能就是该病抗性或称预防性基因。
Objective To investigate the relationship between susceptibility to or susceptibility to tuberculosis and HLA class I antigens in Han Chinese. Methods Using HLA-A, B and C serums, HLA-I antigenic typing was performed on 100 tuberculosis patients and 101 healthy people in northeast China. Results The frequency and relative risk (RR) of HLA-A31, A27 and A35 in TB group were -9.92, 3.6 and 25, respectively. There was no significant difference in the distribution of other alleles in normal subjects and tuberculosis patients. It is suggested that HLA-B27, B35, especially B35 may be one of the susceptible genes of Han Chinese, and HLA-A31 may be the resistance or prophylactic gene.