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目的:探讨人血白蛋白和人丙种球蛋白治疗新生儿溶血的临床效果。方法:对2014年4月至2015年4月本院收治的128例溶血新生儿进行药物治疗,根据治疗药物不同分为试验组和对照组(各64例),对照组采用常规方法治疗(保持水电解质平衡,供给足够能量,维持体温正常,改善循环功能),试验组行人血白蛋白(注射5 g,直到血清白蛋白含量恢复正常)及人丙种球蛋白(1 g·kg-1,于4~6 h静脉滴注,用1次即可)结合治疗,观察两组患儿的临床效果,治疗前和治疗3 d后总胆红素含量,以及治疗1个月的红细胞计数、血红蛋白含量、黄疸消退的时间。结果:试验组的总有效率(96.9%)明显高于对照组(79.7%),差异具有统计学意义(P<0.05);两组患儿治疗3 d后的总胆红素含量、红细胞计数、血红蛋白含量与治疗前均存在明显差异(P<0.05);试验组患儿治疗后的总胆红素含量、红细胞计数、血红蛋白含量与对照组存在明显差异(P<0.05);试验组黄疸消退时间为(4.1±0.9)d,明显短于对照组的(6.9±0.8)d,差异具有统计学意义(P<0.05)。结论:将人血白蛋白和人丙种球蛋白应用于新生儿溶血可有效地改善患儿的总胆红素含量、红细胞计数、血红蛋白含量,缩短黄疸消退时间。
Objective: To investigate the clinical effects of human serum albumin and human gamma globulin in the treatment of neonatal hemolysis. Methods: 128 cases of hemolysis newborn admitted to our hospital from April 2014 to April 2015 were divided into experimental group and control group (64 cases each) according to different therapeutic drugs. The control group was treated by conventional method Water and electrolyte balance, supply enough energy to maintain normal body temperature and improve circulatory function). In the test group, human serum albumin (injection of 5 g until the serum albumin content returned to normal) and human gamma globulin (1 g · kg -1, 4 ~ 6 h intravenous drip, with 1 can) combined with treatment, the clinical efficacy of two groups were observed before treatment and after 3 d of total bilirubin, as well as the treatment of 1 month of red blood cell count, hemoglobin content Jaundice subsided time. Results: The total effective rate (96.9%) in the experimental group was significantly higher than that in the control group (79.7%), the difference was statistically significant (P <0.05). The total bilirubin content, erythrocyte count (P <0.05). The total bilirubin content, erythrocyte count and hemoglobin content in the experimental group were significantly different from those in the control group (P <0.05). The jaundice in the experimental group was subsided The time was (4.1 ± 0.9) d, significantly shorter than that of the control group (6.9 ± 0.8) d, the difference was statistically significant (P <0.05). Conclusion: The application of human serum albumin and human gamma globulin in neonatal hemolysis can effectively improve the total bilirubin content, erythrocyte count, hemoglobin content and shorten the time of jaundice in children.