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目的探讨小肿块型浸润性导管癌(IDC)的声像图特征与免疫组化指标Ki-67、雌激素(ER)、孕激素(PR)及人表皮生长因子受体(Her-2)表达之间的相关性。方法回顾性分析行乳腺超声检查检出的73例肿块最大直径≤2.0 cm IDC患者的临床病理资料,分析其声像图特征与Ki-67、ER、PR及Her-2之间的相关性。结果 73例IDC患者Ki-67、ER、PR和Her-2的阳性率分别为69.9%、68.5%、60.3%和20.5%。肿块最大直径>1 cm组的Ki-67阳性率明显高于肿块最大直径≤1 cm组,差异有统计学意义(P<0.05);肿块最大直径≤1 cm组的ER阳性率明显高于肿块最大直径>1 cm组,差异有统计学意义(P<0.05);肿块形态不规则组、边缘毛刺组的Ki-67阳性率明显高于形态规则组,差异均有统计学意义(P<0.05)。结论小肿块型IDC的声像图特征与免疫组化指标Ki-67、ER、PR及Her-2之间存在相关性,可为临床治疗及判断预后提供一定的参考依据。
Objective To investigate the ultrasonographic features and the expression of immunohistochemical markers Ki-67, estrogen (ER), progesterone (PR) and human epidermal growth factor receptor (Her-2) in small lump type invasive ductal carcinoma (IDC) The correlation between. Methods The clinicopathological data of 73 patients with maximal diameter ≤2.0 cm IDC were retrospectively analyzed. The correlation between the sonographic features and Ki-67, ER, PR and Her-2 was analyzed. Results The positive rates of Ki-67, ER, PR and Her-2 in 73 IDC patients were 69.9%, 68.5%, 60.3% and 20.5% respectively. The positive rate of Ki-67 in the group with the largest diameter> 1 cm was significantly higher than that in the group with the largest diameter ≤1 cm (P <0.05), and the positive rate of ER in the group with the largest diameter ≤1 cm was significantly higher than that with the mass (P <0.05). The positive rate of Ki-67 in tumor group with irregular shape and marginal burr was significantly higher than that in morphological group (P <0.05), and the difference was statistically significant ). Conclusion There is a correlation between the features of immunohistochemical markers Ki-67, ER, PR and Her-2 in small lump type IDC, which may provide reference for clinical treatment and prognosis.