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目的了解某院不同种类清洁手术预防性使用抗菌药物情况，评价其用药合理性及干预效果。方法采用前瞻性监测方法，对某院2012年6月-2013年5月（干预后）清洁手术患者用药情况进行调查，并与2011年2月份出院病例（干预前）进行比较。结果干预后共调查2104例清洁手术患者，其中946例（44.96%）使用了抗菌药物，术前30min预防性使用852例，30-60min预防性使用75例，60-120min预防性使用19例。757例（%）患者预防性使用抗菌药物时间≤24h；170例患者预防性使用抗菌药物时间≤48h；19例患者预防性使用抗菌药物时间≤72h；均为均为一联用药,品种为第一代和第二代头孢菌素类。其中20例患者发生手术部位感染，发生感染者预防用药时间均＜72h。与干预前比较，干预后清洁手术预防性使用抗菌药物更规范、合理。结论手术围手术期预防性使用抗菌药物基本合理，但预防性使用率和停药时间与卫生部的要求还有差距，仍需持续改进，确保达到卫生部要求，使清洁手术预防性使用抗菌药物更规范。“,”OBJECTIVE Different kinds clean know a hospital surgery, prophylactic use of antimicrobial agents, evaluate its rationality and the intervention effect. METHODS Use prospective monitoring method, to a hospital in June 2012 - May 2013 (after the intervention) clean surgery in patients with drug use, and the discharged cases in February 2011 (before intervention). RESULTS Survey 2104 clean surgery patients after intervention, in which 946 cases (44.96%) use of antimicrobial agents, prophylactic use preoperative 30 min 852 cases, 30-60 min preventive use of 75 cases, 60-120 min preventive use 19 cases. 757 patients (%) prophylactic use of antimicrobial drugs for 24 h or less; Prophylactic use of antimicrobial drugs in 170 patients time 48 h or less; Prophylactic use of antimicrobial agents 19 patients time 72 h or less; Are al is a drug, varieties for the first generation and second generation cephalosporin class. 20 patients with surgical site infection, infection prevention medication time < 72 h. Compared with before intervention, intervention after the cleaning operation more normative and reasonable prophylactic use of antimicrobial agents. CONCLUSION Hospital clean surgery perioperative prophylactic use of antimicrobial agents basic reasonable, but preventive usage and drug withdrawal time and the requirements of the ministry of health to a gap, stil need continuous improvement, to fulfil the requirements of the ministry of health, prophylactic use of antimicrobial agents make clean surgery more specification.