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用病理方法确定分泌期宫内膜的组织学日期并与根据后来月经所预计的组织学日期进行比较是临床估价黄体期的基本方法,并提供了一个排卵和宫内膜生理正常状态的概况。宫内膜活检日期最常用于评价不孕时寻找黄体缺陷(LPD)是否存在。为了将临床明确的正常结果范围与实验测定误差产生的结果联系起来且局限实验误差的来源,可以通过评价宫内膜活检的特殊方法使之减少。对25名不孕者在同一部位行两次常规宫内膜活检,福尔马林固定,苏木精/伊红染色,读片编码,随机排列。5名病理学家对25例患者的50张片子阅读两次,两次间隔至少二周。用Noyes等标准标定宫内膜日期。50张片子中,有1张5位评价者读2次认为日期不够,另外2张由一位读者读片2次,其中只一次认为不足。用Box描述的方差分析方法分析同一个人组织内的差异(宫内差异)由同一评价者读两次切片的差异(评价者内差异)和两个评价者之间读片
Histological determination of secretory endometrial histologic dates and comparison with later histological dates based on subsequent menstruation are the basic methods of clinical evaluation of the luteal phase and provide an overview of normal ovulation and endometrial physiology . Endometrial biopsy dates are most commonly used to assess the presence of luteal defect (LPD) when infertility is assessed. In order to link the clinically defined range of normal results to the results of experimental errors and to limit the source of experimental errors, this can be reduced by special methods of evaluating endometrial biopsy. Twenty-five infertile patients underwent two routine endometrial biopsies, formalin fixation, hematoxylin / eosin staining, and reading film coding in the same location, randomly assigned. Five pathologists read 50 of 25 patients for two readings, at least two weeks apart. Noyes and other criteria used to calibrate the endometrial date. Of the 50 films, one of the five reviewers read two times that the date was not enough, and two of the two readers read the film twice, of which only one was considered inadequate. Analysis of variance within the same human tissue (intrauterine differences) by the method of analysis of variance described by Box The differences (intra-evaluator differences) and the interviews between the two evaluators