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目的观察老年晚期非小细胞肺癌采用康莱特注射液联合多西他赛治疗的临床疗效、生活质量及不良反应。方法将82例老年晚期非小细胞肺癌患者随机分成治疗组(康莱特联合多西他赛)和对照组(单用多西他赛),21天为1个疗程,共观察2个疗程,观察两组近期疗效、生活质量及不良反应。结果治疗组近期有效率为58.54%,对照组有效率为36.59%,两组比较差异有统计学意义(P<0.05);治疗组的生活质量优于对照组,差异具有统计学意义(P<0.05);不良反应中血液学毒性主要表现在白细胞和血小板的降低,主要为Ⅰ~Ⅱ级,治疗组较对照组的发生率降低,具有统计学差异;治疗组胃肠道反应发生率均低于对照组,具有统计学意义;治疗组胃肠道反应发生率均低于对照组,统计学上亦有显著性差异(P<0.05),无明显的肝、肾功能损害现象。结论老年晚期非小细胞肺癌用康莱特注射液联合多西他赛治疗的疗效较好,不仅提高了患者对化疗的耐受性,还提高了患者的生活质量。
Objective To observe the clinical efficacy, quality of life and adverse reactions of elderly patients with advanced non-small cell lung cancer treated with KLT and Docetaxel. Methods 82 patients with advanced non-small cell lung cancer were randomly divided into treatment group (Kanglaite combined with docetaxel) and control group (docetaxel alone), 21 days for a course of treatment, were observed for 2 courses, observed Two groups of short-term efficacy, quality of life and adverse reactions. Results The effective rate was 58.54% in the treatment group and 36.59% in the control group, the difference between the two groups was statistically significant (P <0.05). The quality of life of the treatment group was better than that of the control group (P < 0.05) .Hematological toxicity in adverse reactions mainly manifested in the reduction of white blood cells and platelets, mainly Ⅰ ~ Ⅱ grade, the treatment group than the control group, the incidence decreased, with statistical differences; the incidence of gastrointestinal reactions in the treatment group were low In the control group, there was statistical significance. The incidence of gastrointestinal reaction in the treatment group was lower than that in the control group, and there was also a statistically significant difference (P <0.05). There was no obvious liver and kidney dysfunction. Conclusions Elderly patients with non-small cell lung cancer with KLT combined with docetaxel have better curative effect, which not only improves the patient’s tolerance to chemotherapy but also improves the quality of life of patients.