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血吸虫病家兔連續14天每天口服酒石酸銻鉀20毫克/公斤的一組无明显疗效,而每天口服30及40毫克/公斤的两組动物有相当的疗效,減虫率分別为60.8％及63.3％。三组动物平均血銻含量相似,分別为0.49,0.44及0.50微克/克,因而不能証明血銻含量高低与疗效高低相关。 連續3天靜脉滴流組家兔的血銻虽无高浓度出現,但疗效并不低于3天6針注射組,因此不能証明高浓度血銻是影响酒石酸銻鉀治疗家兔血吸虫病疗效的主要因素。口服酒石酸銻鉀剂量大者尿內銻量亦多,是故以后欲了解口服銻剂吸收情况时可考虑用尿銻含量的測定来代替血銻的测定。
Schistosoma japonicum rabbits administered with 20 mg / kg antimony potassium tartrate once daily for 14 consecutive days showed no significant effect, while two groups of animals orally administered 30 and 40 mg / kg orally had comparable therapeutic effects with the worm reduction rates of 60.8% and 63.3, respectively %. The average blood antimony levels in the three groups of animals were similar, 0.49, 0.44 and 0.50 μg / g, respectively, thus failing to demonstrate that the level of antimony in blood was correlated with the level of efficacy. Although there was no high concentration of blood antimony in rabbits in intravenous drip for 3 consecutive days, the effect was not lower than that of 6-day injection in 3 days. Therefore, it can not be proved that high concentration of blood antimony affects the efficacy of antimony potassium tartrate in the treatment of schistosomiasis in rabbits major factor. Oral antimony potassium dose of large amounts of urinary antimony is also more, it is therefore later to understand the absorption of oral antimony agent may consider the determination of urine antimony content instead of the determination of blood antimony.