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脂蛋白(a)(Lp(a))近年来已为人们所重视。Lp(a)的物理和化学性质与低密度脂蛋白(LDL)相似,这两种脂蛋白的主要蛋白都是载脂蛋白B_(100)(apoB_(100))。但是Lp(a)含有a 抗原决定基的糖基化蛋白,且经二硫键与apoB_(100)相连。由于这个糖基化蛋白使得Lp(a)在琼脂糖凝胶电泳中的迁移率与前β脂蛋白一致,其密度是1.050～1.120g/ml。Lp(a)的蛋白和脂类组成在个体间和个体内具有很大的不均匀性,而且它不是极低密度脂蛋白LDL 和乳糜微粒的代谢产物,是作为一种单独的脂蛋白被合成。血清中的脂蛋白(a)不能转变成其它脂蛋白。Lp(a)与细胞表面受体结合
Lipoprotein (a) (Lp (a)) has drawn great attention in recent years. The physical and chemical properties of Lp (a) are similar to those of low density lipoprotein (LDL). The main proteins of both lipoproteins are apolipoprotein B 100 (apoB 100). However, Lp (a) contains an a-epitope glycosylated protein and is disulfide bonded to apoB_ (100). Because of this glycosylated protein, the mobility of Lp (a) in agarose gel electrophoresis is consistent with the pre-beta lipoprotein, with a density of 1.050 to 1.120 g / ml. The protein and lipid composition of Lp (a) is highly heterogeneous between individuals and individuals, and it is not a metabolite of very low density lipoprotein LDL and chylomicrons and is synthesized as a single lipoprotein . Serum lipoprotein (a) can not be converted to other lipoproteins. Lp (a) binds to cell surface receptors