新的氧化应激标志物与冠状动脉疾病患者的死亡风险相关

• 作 者: 刘莉 叶鹏 Patel RS Ghasemzadeh N Eapen DJ Sher S Arshad S Ko YA Veledar E Samady H Zafari AM Sperling L Vaccarino V Jones DP Quyyumi AA
• 出 处: 中华高血压杂志
• 发表日期: 2015年11期
• 关键词: 氧化应激 高效液相色谱仪 冠状动脉 冠状动脉造影 半胱氨酸 谷胱甘肽 定量分析 死亡风险 自由基 氨基

该文旨在验证新出现的以氨基硫醇为标志物的非自由基介导的氧化应激与临床预后的关系。方法:纳入行冠状动脉造影的1411例患者(平均63岁,男性占66%),应用高效液相色谱仪定量分析还原的(半胱氨酸和谷胱甘肽)和氧化的(半胱氨酸和谷胱甘肽二硫化物)氨基硫醇水平。结果:所有患者平均随访(4.7±

The aim of this paper is to validate the emerging relationship between non-radical-mediated oxidative stress with aminothiol and clinical prognosis. METHODS: A total of 1411 patients undergoing coronary angiography (mean, 63 years, 66%) were enrolled in this study. High performance liquid chromatography (HPLC) was used to quantify reduced (cysteine ​​and glutathione) and oxidized Acid and glutathione disulfide) aminothiol levels. Results: All patients were followed up on average (4.7 ±