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作者在测定肝硬化和肾病综合征患者血清三种甲状腺素结合蛋白:甲状腺素结合球蛋白(TBG)、前白蛋白(TBPA)、白蛋白含量的同时,应用聚丙烯酰胺凝胶电泳与放射自显影分析它们的结合力。本文两组病员血清T_3和T_4均明显降低。肝病组患者血清白蛋白浓度与甲状腺激素呈明显正相关;TBPA-T_4-[~(125)I]结合率比其血清浓度减低更为明显;TBG浓度无明显改变,但其结合率增加。肾病组患者血清白蛋白、TBG浓度显著降低,但TBG-T_4-[~(125)I]结合率增加;TBPA浓度虽无改变,但其与T_4结合量则减少。本文表明两组患者TBPA-T_4-[~(125)I]结合率均有下降,而TBG-T_4-[~(125)I]结合率的变化处于复杂的动态平衡,与原发病的病理生理变化相符合。
In the determination of serum thyroxine binding protein (TBG), prealbumin (TBPA) and albumin in serum of patients with cirrhosis and nephrotic syndrome, polyacrylamide gel electrophoresis Develop to analyze their binding power. Two groups of patients in this paper serum T 3 and T 4 were significantly lower. The level of serum albumin in patients with liver disease was positively correlated with thyroid hormone. The binding rate of TBPA-T_4- [125 (125) I] was significantly lower than that of serum. The concentration of TBG did not change but the binding rate increased. Serum albumin and TBG levels were significantly decreased in patients with nephropathy, but the binding rate of TBG-T 4 - [~ (125) I] was increased; while the TBPA concentration was unchanged, the binding capacity to TBI decreased. This article shows that TBPA-T_4- [~ (125) I] binding rate decreased in both groups, while the binding rate of TBG-T_4- [~ (125) I] was in complex dynamic balance. Physiological changes consistent.