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目的探讨乙型肝炎病毒相关性肾炎的临床病理情况及其相关关系。方法回顾性分析2004年1月至2011年2月诊断的69例乙型肝炎病毒相关性肾炎(HBV-GN)患者的临床和病理特点。结果 69例HBV-GN患者中男48例,女21例,男女之比为2.29∶1,平均年龄(38±16)岁。病理表现为膜性肾病19例,膜增生性肾小球肾炎14例,系膜增生性肾炎13例,局灶节段性肾小球硬化13例,其他病理类型10例;临床表现为肾病综合征25例。结论 HBV-GN中以男性居多,表现为肾功能不全者少见,69例中仅6例血清肌酐>200μmol/L。病理类型以膜性肾病最多,其次为膜增生性肾小球肾炎、系膜增生性肾炎和局灶节段性肾小球硬化。
Objective To investigate the clinicopathological characteristics of hepatitis B virus-associated nephritis and its relationship. Methods The clinical and pathological features of 69 patients with hepatitis B virus associated nephritis (HBV-GN) diagnosed from January 2004 to February 2011 were retrospectively analyzed. Results 69 cases of HBV-GN patients, 48 males and 21 females, the ratio of male to female was 2.29:1, mean age (38 ± 16) years. Pathological manifestations of membranous nephropathy in 19 cases, 14 cases of membranoproliferative glomerulonephritis, mesangial proliferative glomerulonephritis in 13 cases, focal segmental glomerulosclerosis in 13 cases, other pathological types in 10 cases; clinical manifestations of nephrotic syndrome Twenty-five cases. Conclusions Most of the patients with HBV-GN are male, with rare renal dysfunction. Only 6 of 69 patients have serum creatinine> 200μmol / L. Pathological type membranous nephropathy, followed by membranoproliferative glomerulonephritis, mesangial proliferative glomerulonephritis and focal segmental glomerulosclerosis.