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目的探讨转移相关基因(MTA-1)及增殖细胞核抗原(PCNA)在腺性膀胱炎中的表达和临床意义。方法选取本院膀胱移行细胞癌标本、腺性膀胱炎标本、正常膀胱黏膜标本各20例,使用免疫组织化学方法分别进行检测标本中的MTA-1及PCNA的表达。记录三组标本中MTA-1和PCNA的表达阳性率。结果 MTA-1在三组中的表达阳性率相比较差异有统计学意义(P<0.05),和正常膀胱黏膜比较MTA-1在其他两组中表达的阳性率较高(P<0.05),和膀胱移行细胞癌比较MTA-1在腺性膀胱炎中表达阳性率较低(P>0.05)。PCNA在三组中的表达阳性率相比较差异有统计学意义(P<0.05),在腺性膀胱炎和膀胱移行细胞癌中表达阳性率较高(P<0.05),和膀胱移行细胞癌比较在腺性膀胱炎中表达阳性率较低(P<0.05)。结论 MTA-1及PCNA的表达在膀胱肿瘤中具有十分重要的意义,对膀胱炎的性质和发展具有预测功能。
Objective To investigate the expression and clinical significance of metastasis-associated gene (MTA-1) and proliferating cell nuclear antigen (PCNA) in cystitis glandularis. Methods Twenty cases of transitional cell carcinoma of bladder, cystitis glandularis and normal bladder mucosa were selected in this study. Immunohistochemistry was used to detect the expression of MTA-1 and PCNA respectively. Record the positive expression rate of MTA-1 and PCNA in three groups of specimens. Results The positive rate of MTA-1 expression in the three groups was significantly different (P <0.05). Compared with normal bladder mucosa, the positive rate of MTA-1 expression in the other two groups was higher (P <0.05) Compared with bladder transitional cell carcinoma, the positive rate of MTA-1 in cystitis glandularis was lower (P> 0.05). The positive expression rates of PCNA in three groups were statistically significant (P <0.05), and were higher in cystitis cystitis and transitional cell carcinoma of the bladder (P <0.05). Compared with bladder transitional cell carcinoma The positive rate was lower in cystitis glandularis (P <0.05). Conclusions The expression of MTA-1 and PCNA is of great significance in bladder neoplasms and predicts the nature and development of cystitis.