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慢性阻塞性肺疾病目前已经成为全球第3大死因的慢性疾病，疾病病程长，经济负担重。现已发现多种致病原因，在临床患者的调查研究中发现，慢性阻塞性肺疾病多与炎症反应相关。本文主要叙述白细胞介素1β、白细胞介素6及肿瘤坏死因子α 3种慢性阻塞性肺疾病中相关的炎症因子，以及这些炎症因子引起的不同病理改变。因此，对炎症因子的作用机制加以研究，能够为个性化治疗慢性阻塞性肺疾病提供新的思路。“,”Chronic obstructive pulmonary disease (COPD) has become the third leading cause of death in the world.The disease has a long course and a heavy economic burden.A variety of causes have been found.In clinical patient investigations, it has been found that COPD is mostly related to inflammation.This article mainly describes three kinds of inflammatory factors interleukin-1β, interleukin-6 and tumor necrosis factor-α in COPD, and the different pathological changes caused by these inflammatory factors.Therefore, studying the mechanism of inflammatory factors can provide new ideas for personalized treatment of COPD.