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目的：观察中等剂量维生素Ａ对四氯化碳（ＣＣｌ４）诱导的实验性大鼠肝纤维化的影响。方法：在四氯化碳诱导大鼠肝纤维化的同时，给以１００ｍｇ／ｋｇ体重维生素Ａ皮下注射。检测在早（３周）、中（６周）、晚（１２周）期大鼠肝组织羟脯氨酸含量及血清中透明质酸及谷丙转氨酶水平，并观察肝脏的组织病理改变。结果：治疗组早期血清透明质酸及组织病理学的炎症程度均显著低于ＣＣｌ４对照组（Ｐ＜０．０５），中、晚期肝组织羟脯氨酸含量及晚期肝组织学纤维化程度虽低于ＣＣｌ４对照组，但相差不显著。结论：上述剂量维生素Ａ能减轻ＣＣｌ４所致大鼠的早期肝脏损害，它可能有益于减轻其后的肝纤维化。
Objective: To observe the effect of medium dose of vitamin A on carbon tetrachloride (CCl4) -induced hepatic fibrosis in rats. Methods: CCl 4 -induced hepatic fibrosis at the same time, given 100mg / kg body weight of vitamin A subcutaneous injection. The content of hydroxyproline in serum and the level of hyaluronic acid and alanine aminotransferase in the early (3 weeks), middle (6 weeks) and late (12 weeks) rats were measured. The pathological changes of the liver were observed. Results: The serum levels of hyaluronic acid and histopathology in the early treatment group were significantly lower than those in the CCl4 control group (P <0.05). The contents of hydroxyproline in the middle and late stages of liver tissue and the degree of advanced liver fibrosis Lower than CCl4 control group, but the difference is not significant. Conclusion: The above dose of vitamin A can reduce the early liver damage caused by CCl4 in rats, it may be beneficial to reduce subsequent liver fibrosis.