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目的总结成人急性白血病 19例长期生存患者临床资料。方法根据不同类型的急性白血病 ,采用不同方法的化疗方案。结果成人急性白血病存活 5年以上 19例。其中 M313例 ,M2 4例 ,AL L 2例。 M3患者经 ATRA诱导分化获完全缓解后以 HA、DA方案巩固2～ 3个疗程 ,以后化疗 -ATRA交替治疗。一例 M3巩固治疗后不规则治疗 1年停药 ,已持续完全缓解 110个月。4例 M2 经 HA、DA方案诱导化疗 ,3例一疗程获完全缓解。结论白血病类型、诱导期骨髓抑制性化疗、首次完全缓解期是影响急性白血病长期生存的重要因素 ;少数长期生存患者具个体特异性。
Objective To summarize the clinical data of 19 patients with long-term survival in adult acute leukemia. Methods According to different types of acute leukemia, different methods of chemotherapy were used. Results Adult acute leukemia survived more than 5 years in 19 cases. There were M313 cases, M2 cases, and AL L cases. M3 patients were completely relapsed after induction of differentiation by ATRA, followed by consolidation with HA, DA regimens for 2 to 3 courses, followed by alternating chemotherapy-ATRA treatment. One case of irregular treatment after M3 consolidation therapy was discontinued for 1 year and sustained complete remission for 110 months. Four cases of M2 were induced by HA and DA regimen, and 3 cases received complete remission in one course. Conclusion Leukemia type, induction phase myelosuppressive chemotherapy and first complete remission phase are important factors affecting the long-term survival of acute leukemia; a few long-term survival patients are individual-specific.