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本文先用计算机预测、后用51Cr4h释放分析证实的方法，对丙型肝炎病毒（HCV）核心区蛋白（C蛋白）上，HLA－A2限制性CTL识别表位进行了鉴别。结果发现，2名感染HCV的HLA－A2阳性供血员的外周血单个核细胞（PBMc）对ALAHGVRAL（core150～158）肽段标记的自体靶细胞有溶解作用，杀伤率分别为37．5％和15．8％；用抗CD4mAb阻断后杀伤率无明显变化，而用抗CDSmAb阻断后明显减少，提示该条肽段可能为HLA－A2限制性CTL识别表位。
In this paper, HLA-A2-restricted CTL recognition epitopes on the core protein (C protein) of hepatitis C virus (HCV) were identified by computer prediction and post-51Cr4h release assay. The results showed that peripheral blood mononuclear cells (PBMc) of two HLA-A2 positive blood donors infected with HCV had lytic effects on ALAHGVRAL (core150 ~ 158) labeled autologous target cells with killing rates of 37.5% and 15.8%. After killing with anti-CD4 mAb, there was no significant change in killing rate, but significantly decreased with anti-CDS mAb, suggesting that this peptide may be HLA-A2 restricted CTL recognition epitope.