乙型肝炎的免疫发病机理

• 作 者: 郑培君 张定凤
• 机 构: 上海第一医学院儿科医院传染科,重庆医学院第二医院传染病研究室,
• 出 处: 国外医学(儿科学分册)
• 发表日期: 1983年05期
• 关键词: 乙型肝炎 免疫发病机理 肝细胞损害 慢性携带者 多聚酶 病毒基因 DNA 免疫反应 免疫调节 巨噬细胞

乙型肝炎(下称乙肝)作为一个常见的传染病已日益受到人们的重视。根据WHO的资料,世界上乙肝病毒(HBV)的慢性携带者约有1亿7千6百万。乙肝的致病因素一般认为有3方面:(1)病毒因素如病毒的亚型和感染的数量。HBV为环状DNA病毒,其DNA双股螺旋有部分是单股的,需依靠DNA多聚酶修补。有缺损的HBV颗粒可能与感染持续存在有关。近年认为HBV的

Hepatitis B (hereinafter referred to as hepatitis B) as a common infectious disease has received increasing attention. According to WHO, there are about 167 million chronic carriers of hepatitis B virus (HBV) in the world. The pathogenic factors of hepatitis B are generally considered to have 3 aspects: (1) viral factors such as the virus subtypes and the number of infections. HBV is a circular DNA virus, part of its DNA double helix is ​​single-strand, depending on DNA polymerase repair. Defective HBV particles may be associated with the persistence of infection. In recent years that the HBV