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[目的]通过对灭幼脲缓释微胶囊的制备和对其性能的测试来提高灭幼脲的稳定性与环境的相容性。[方法]采用壳聚糖和海藻酸钠作为囊壁材料,利用静电吸附层层自组装技术(Layer-by-Layer,LbL法)制备灭幼脲微胶囊。正交优化灭幼脲微胶囊制备工艺,利用扫描电子显微镜和激光共聚焦显微镜表征微胶囊表面结构,研究了微胶囊的体外释放行为。[结果]实验结果表明:分别加入1 mL海藻酸钠(1.0 g/L)、1 mL壳聚糖(1.0 g/L)、20 mg灭幼脲、1 mL氯化钙(1.0 g/L)能得到相对更好的结果。正交试验4个因素中,氯化钙质量浓度对评估结果影响最大;利用优化后的体系制备的灭幼脲微胶囊,平均粒径为10μm,Zeta电位为+23.5 mV;载药量和包封率分别为(68.8±0.86)%和(69.1±0.86)%。[结论]利用这种方法制备的灭幼脲微胶囊具备明显的缓释性能。
[Objective] The research aimed to improve the compatibility of chlorbenzuron with the environment by preparing and testing its performance. [Method] Chitosan and sodium alginate were used as wall materials to prepare diflubenzuron microcapsules by layer-by-layer (LbL) method. The microcapsules were prepared by orthogonal test. The surface structure of the microcapsules was characterized by scanning electron microscopy (SEM) and confocal laser scanning microscopy (SEM). The in vitro release behaviors of microcapsules were studied. [Result] The results showed that 1 mL sodium alginate (1.0 g / L), 1 mL chitosan (1.0 g / L), 20 mg diflubenzuron, 1 mL calcium chloride (1.0 g / L) Can get relatively better results. Among the four factors, the calcium chloride concentration had the greatest influence on the evaluation results. The microcapsule prepared by the optimized system had an average particle size of 10μm and a Zeta potential of +23.5 mV. Sealing rates were (68.8 ± 0.86)% and (69.1 ± 0.86)%, respectively. [Conclusion] The microcapsule prepared by this method has obvious sustained-release properties.