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目的研究神经激肽Ｂ受体（ＮＫ３受体）与机体渗透压调节之间的可能关系。方法用双重免疫组织化学染色技术，高渗刺激采用静脉内注射１．５ｍｏｌ／ＬＮａＣｌ的方法，观察了下丘脑室旁核和视上核内ＮＫ３受体阳性神经元在高渗刺激下的Ｆｏｓ表达情况。结果高渗盐水可诱导下丘脑室旁核和视上核内大量神经元表达Ｆｏｓ。在室旁核，双标细胞约占ＮＫ３受体阳性神经元的８８％，约占Ｆｏｓ阳性细胞的７１％；在视上核的主部，双标细胞约占ＮＫ３受体阳性神经元的７４％，约占Ｆｏｓ阳性细胞的４３％。结论室旁核和视上核内ＮＫ３受体阳性神经元可能参与大鼠渗透压调节过程。
Objective To study the possible relationship between neurokinin B receptor (NK3 receptor) and the regulation of osmotic pressure. Methods Double immunohistochemical staining technique was used to observe the Fos expression of NK3 receptor positive neurons in the paraventricular nucleus and supraoptic nucleus of hypothalamus under the condition of hypertonic stimulation by intravenous injection of 1.5mol / L NaCl. Happening. Results Hypertonic saline induced the expression of Fos in a large number of neurons in paraventricular nucleus and supraoptic nucleus of hypothalamus. Paraventricular nucleus, double labeled cells account for about 88% of NK3 receptor-positive neurons, accounting for 71% of Fos-positive cells; in the main part of the supraoptic nucleus, double-labeled cells account for about NK3 receptor-positive neurons 74 %, Accounting for 43% of Fos-positive cells. Conclusion NK3 receptor positive neurons in paraventricular nucleus and supraoptic nucleus may be involved in osmoregulation process in rats.