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目的:探讨早期经阴道穿刺放腹水治疗中重度卵巢过度刺激综合征(ovarian hyperstimulation syndrome,OHSS)的临床效果。方法:回顾性分析2014年1—9月在本院生殖医学中心行体外受精/卵胞浆内单精子注射-胚胎移植(IVF/ICSI-ET)术后出现中、重度OHSS的96例门诊患者临床资料。根据OHSS发生的时间分为早发型和晚发型。根据经阴道穿刺放腹水处理治疗的时间早晚,又进一步分为早处理组和晚处理组。结果:(1)中、重度OHSS患者早处理和晚处理组年龄、体重指数(BMI)、基础卵泡刺激素(FSH)等基本临床资料指标差异无统计学意义。其受精率、获卵数、流产率等指标差异也无统计学意义。(2)在两种OHSS分型患者中,早处理和晚处理组经阴道穿刺放腹水量差异均有统计学意义。结论:对于门诊管理的OHSS患者,无论是早发型还是晚发型,建议及早经阴道穿刺放腹水治疗,该治疗手段不增加流产率,降低了治疗后住院率,安全经济有效。
Objective: To investigate the clinical effect of transvaginal puncture ascites in the treatment of moderate and severe ovarian hyperstimulation syndrome (OHSS). Methods: A total of 96 outpatients with moderate to severe OHSS who underwent in vitro fertilization / intracytoplasmic sperm injection / embryo transfer (IVF / ICSI-ET) from January to September 2014 in our hospital were retrospectively analyzed. clinical information. According to the time of OHSS is divided into early and late hair type. According to transabdominal puncture ascites treatment of time sooner or later, further divided into early treatment group and late treatment group. Results: (1) There was no significant difference in the basic clinical data such as age, body mass index (BMI) and basal follicle stimulating hormone (FSH) between the moderate and severe OHSS patients in the early and late treatment groups. The fertilization rate, number of oocytes, miscarriage rate and other indicators of difference was not statistically significant. (2) In the two types of OHSS patients, there were significant differences in translumenal ascites volume between the early and late treatment groups. Conclusions: For OHSS patients with outpatient management, either early or late hair style, it is recommended that ascites be treated by vaginal puncture as early as possible. This treatment method does not increase the abortion rate, reduces the post-treatment hospitalization rate, and is safe, economical and effective.