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目的探讨重症手足口病发病的主要危险因素,为今后的防治提供科学依据。方法利用Meta分析方法对2008年至今国内外已发表的关于重症手足口病危险因素的病例对照研究进行定量综合分析。结果共纳入16篇文献,病例3 147例,对照6 163例,有意义因素的OR值分别为:年龄<3岁(2.10)、EV71阳性(3.39)、散居儿童(1.87)、血糖>9mmol/L(21.17)、首诊医院级别(3.17)、体温>39℃且超过3d(5.93)、WBC>12×109/L(3.83)和首诊非手足口病(3.91)。结论低龄婴幼儿、EV71阳性、持续高热、白细胞/血糖升高、首诊医院级别和首诊非手足口病是重症手足口病的危险因素。而出诊天数、现住址为农村、早产儿和流动人口与重症手足口病无关联。
Objective To explore the main risk factors of HFMD and provide a scientific basis for future prevention and treatment. Methods Meta-analysis was used to analyze the published case-control studies on the risk factors of HFMD in China and other countries since 2008. Results A total of 16 articles were included, including 3 147 cases and 6 163 cases. The OR of significant factors were as follows: age <3 years old (2.10), EV71 positive (3.39), diaspora (1.87), blood glucose> 9mmol / L (21.17), the first visit to the hospital (3.17), body temperature> 39 ℃ and beyond 3d (5.93), WBC> 12 × 109 / L (3.83) and the first diagnosis of non-hand-foot-mouth disease (3.91). Conclusions Young infants and young children, EV71 positive, persistent fever, leukocyte / hyperglycemia, the first hospital-level and first diagnosis of non-hand-foot-mouth disease are risk factors for HFMD. The number of days of treatment, the current address for the rural, premature infants and migrants are not associated with severe HFMD.