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目的评估和比较异丙酚，硫喷妥钠和依托咪酯用于腹腔镜胆囊切除术麻醉中诱导情况，麻醉稳定性，苏醒情况和麻醉并发症。方法选择６０例行腹腔镜胆囊切除术的病人，随机分为３组，Ａ组硫喷妥钠用于麻醉诱导，３０％氧化亚氮－七氟醚用于麻醉维持；Ｂ组异丙酚用于麻醉诱导和维持；Ｃ组依托咪酯用于麻醉诱导和维持。结果各组诱导意识消失时间依次为３７．７±１．０ｓ，４９．９±１．８ｓ，５７．３±２．０ｓ，麻醉后睁眼时间依次为１３．９±０．８ｍｉｎ，９．４±０．４ｍｉｎ，１２．３±０．７ｍｉｎ。各组间比较差异均有显著性（Ｐ均＜０．０１）。异丙酚组苏醒后无１例复睡。结论异丙酚诱导迅速，可以提供一个稳定的腹腔镜麻醉，而不需要大量的其它静脉麻醉药，苏醒最快，且苏醒质量好，术后并发症少。
Objectives To evaluate and compare the effects of propofol, thiopental and etomidate on the induction of anesthesia during laparoscopic cholecystectomy, anesthetic stability, wakefulness and anesthetic complications. Methods Sixty patients undergoing laparoscopic cholecystectomy were randomly divided into three groups. Group A received thiopental for anesthesia induction and 30% nitrous oxide-sevoflurane for anesthesia maintenance. Group B received propofol Induction and maintenance of anesthesia; group C etomidate for anesthesia induction and maintenance. Results The induction time of each group was 37.7 ± 1.0s, 49.9 ± 1.8s and 57.3 ± 2.0s, respectively, and the time to open eyes was 13.9 ± 0.8min after anesthesia. 4 ± 0.4 min, 12.3 ± 0.7 min. The differences between the groups were significant (P all <0.01). Propofol group no recovery after sleep recovery. Conclusions Propofol is rapidly induced and provides a stable laparoscopic anesthetic without the need for a large number of other intravenous anesthetics, which results in the fastest recovery, good wake quality and few postoperative complications.