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本文对一组大系列不伴肝硬变的慢性乙型肝炎患者进行了长达16年的随访,分析了临床和组织学转归,以及各种预后因素。 105例患者都符合下列要求:(1)HBsAg阳性并且血清丙氨酸转氨酶(ALT)持续升高(正常<55IU/L)至少达12个月;(2)丁型肝炎病毒(HDV)标志物均阴性,(3)肝活检标本符合慢性迁延性肝炎或慢性活动性肝炎而无组织学和临床方面肝硬变的证据(消瘦,食道静脉曲张,腹水);(4)从作出组织学诊断起随访至少达12个月;(5)观察期内作一次随访性肝活检。本组病例不包括酒精摄入超过80g/日以及使用可能导致肝损害药物的患者。 105例患者中,男80例,女25例,平均年
In this paper, a series of large series of patients with chronic hepatitis B without cirrhosis were followed up for 16 years. Clinical and histological findings and various prognostic factors were analyzed. All of the 105 patients met the following criteria: (1) HBsAg positive and serum alanine aminotransferase (ALT) consistently increased (normal <55 IU / L) for at least 12 months; (2) markers of hepatitis D virus (3) evidence of liver biopsy specimens consistent with chronic persistent hepatitis or chronic active hepatitis without histological and clinical cirrhosis (emaciation, esophageal varices, ascites); (4) from histologic diagnosis Followed up for at least 12 months; (5) during the observation period for a follow-up liver biopsy. This group of patients does not include alcohol intake of more than 80g / day and the use of drugs that may lead to liver damage in patients. Of the 105 patients, 80 were male and 25 were female, with an average of years