【摘 要】
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Drinking culture has high significance in both China and the world, whether in the entertainment sector or in social occasions;according to the World Health Organization\'s 2018 Global Alcohol and Health Report, about 3 million people died from excessiv
【机 构】
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Jiangsu Key Laboratory of Marine Bioresources and Environment,Co-Innovation Center of Jiangsu Marine
【出 处】
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浙江大学学报（英文版）（B辑：生物医学和生物技术）
论文部分内容阅读
Drinking culture has high significance in both China and the world, whether in the entertainment sector or in social occasions;according to the World Health Organization\'s 2018 Global Alcohol and Health Report, about 3 million people died from excessive drinking in 2016, accounting for 5.3％ of the total global deaths that year. Oxidative stress and inflam-mation are the most common pathological phenomena caused by alcohol abuse (Snyder et al., 2017). Scutel-larin, a kind of flavonoid, is one of the main active ingredients extracted from breviscapine. It exerts anti-inflammatory, antioxidant, and vasodilation effects, and has been used to treat cardiovascular diseases and alcoholic liver injury. Although scutellarin can effect-ively alleviate multi-target organ injury induced by different forms of stimulation, its protective effect on alcoholic brain injury has not been well-defined. There-fore, the present study established an acute alcohol mice brain injury model to explore the effect of scutellarin on acute alcoholic brain injury. The study was carried out based on the targets of oxidative stress and inflam-mation, which is of great significance for the targeted therapy of clinical alcohol diseases.
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