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对麻醉后的三组狗(每组三只)分别给予以下三种异搏定舌下含服剂:盐酸异搏定粉剂(1~#);盐酸异搏定和碳酸氢钠粉剂(2~#);和溶入增溶剂聚乙二醇中的游离异搏定(3~#)。异搏定的剂量相当于40毫克。使用快速心房刺激诱发心房纤颤。测定不同制剂最大药理作用(心室率最大程度的降低)到达时间和最高平均血浓度。对3~#
The three groups of dogs after anesthesia (three in each group) were given the following three sublingual sublingual subconjunctival agents: verapamil hydrochloride (1 ~ #); verapamil hydrochloride and sodium bicarbonate powder (2 ~ #); And dissolve in solubilizer polyethylene glycol in free verapamil (3 ~ #). Verapamil dose equivalent to 40 mg. Use of rapid atrial stimulation induces atrial fibrillation. Determination of the maximum pharmacological effects of different formulations (maximum reduction of ventricular rate) arrival time and the highest average blood concentration. For 3 ~ #