论文部分内容阅读
在制药原料药及中间体尤其是抗生素合成生产过程中,一些反应需在-40℃～-75℃的低温条件下进行。传统的冰盐水供冷系统供冷温度难以达到要求。目前,国外厂家多采用深冷机组进行降温,国内厂家多以液氮作为冷源,将液氮直接通入反应液或通过内盘管汽化吸热降温。由于使用液氮降温存在工艺温度不易控制、液氮冷量损失大、降温成本高、生产难以上规模及受供应和储存条件的限制等缺点,一些厂家也开始
In the pharmaceutical raw materials and intermediates, especially antibiotic synthesis process, some reactions need to be in the low temperature of -40 ℃ ~ -75 ℃. The traditional ice brine water cooling system is difficult to meet the requirements of the cooling temperature. At present, foreign manufacturers use more cryogenic units to cool more domestic manufacturers mostly liquid nitrogen as a cold source, the liquid nitrogen directly into the reaction liquid or through the coil cools endothermic cooling. Due to the use of liquid nitrogen cooling process temperature is not easy to control, large loss of liquid nitrogen cold, high cooling costs, the production is difficult to scale and subject to supply and storage conditions, shortcomings, some manufacturers have begun