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目的对二甲双胍联合甘精胰岛素治疗本地区2型糖尿病的临床效果进行探讨与分析。方法对本医院在2010年2月至2011年12月之间收治的48例2型糖尿病患者的临床资料进行回顾性分析与总结。随机分为对照组与治疗组,两组患者共同的基本治疗方法为口服二甲双胍,同时配合饮食指导与适当运动。观察组患者在接受基本治疗的基础上给予甘精胰岛素,对照组患者给予诺和灵N,在进行治疗后将两组患者的空腹血糖、血糖控制达标时间、糖化血红蛋白等相关指标与治疗前进行对比分析。结果治疗组患者的空腹血糖、糖化血红蛋白量均低于对照组,差异有统计学意义(P<0.05)。并且治疗组患者的血糖控制达标时间也明显短于对照组,差异显著,具有统计学意义(P<0.05)。结论二甲双胍联合甘精胰岛素对延缓2型糖尿病患者的病情发展起到了明显的作用。空腹血糖以及糖化血红蛋白等得到有效控制,值得进行临床推广与应用。
Objective To investigate and analyze the clinical effect of metformin combined with insulin glargine in the treatment of type 2 diabetes mellitus in the area. Methods The clinical data of 48 patients with type 2 diabetes admitted to our hospital from February 2010 to December 2011 were retrospectively analyzed and summarized. Randomly divided into control group and treatment group, the two groups of patients with the basic treatment of oral metformin, with dietary guidance and appropriate exercise. Patients in the observation group were given insulin glargine on the basis of basic treatment while those in the control group were given noradrenaline. After treatment, the relevant indicators of fasting blood glucose, glycemic control time and glycosylated hemoglobin were compared with those before treatment Comparative analysis. Results The fasting blood glucose and glycosylated hemoglobin in the treatment group were lower than those in the control group (P <0.05). And the treatment group patients with glycemic control time was significantly shorter than the control group, the difference was significant, with statistical significance (P <0.05). Conclusion Metformin combined with insulin glargine has a significant effect on the progression of patients with type 2 diabetes. Fasting blood glucose and glycosylated hemoglobin have been effectively controlled, worthy of clinical promotion and application.