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对４８例外阴鳞状细胞癌的淋巴结转移相关因素进行了临床病理分析，并应用流式细胞术（ｆｌｏｗｃｙｔｏｍｅｔｒｙＦＣＭ）对其中的３１例检测了细胞增殖活力、ＤＮＡ含量、ｒａｓＰ２１等。结果显示：发生淋巴结转移的外阴癌细胞的Ｓ％、ＰＩ和ＤＩ值显著高于未发生转移者；临床期别晚、组织分化差的外阴癌的淋巴结转移率显著增高。认为临床分期、Ｓ％、ＰＩ、ＤＩ值及组织学分级是影响外阴癌淋巴结转移的重要因素。
The clinicopathological factors of lymph node metastasis in 48 cases of vulvar squamous cell carcinoma were analyzed. Flow cytometry (FCM) was used to detect the cell proliferation activity, DNA content and rasP21 in 31 of them. The results showed that the S%, PI and DI of vulvar cancer cells with lymph node metastasis were significantly higher than those without metastasis; the lymph node metastasis rate of vulvar cancer with poorly differentiated tissue was significantly increased after the clinical period. It is considered that the clinical stage, S%, PI, DI value and histological grade are the important factors affecting the lymph node metastasis of vulvar cancer.