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目的观察卡培他滨治疗老年晚期胃癌的近期疗效及毒副反应。方法我科于2006年12月至2009年12月,应用卡培他滨治疗35例老年晚期胃癌患者,卡培他滨2500mg/m2,每日2次口服,第1～14天;21d为1周期;连用4个周期后评价疗效。结果 35例患者中CR0例(0%)、PR10例(28.57%)、SD13例(37.14%)、PD12例(34.29%)。26例相关症状改善。主要毒副反应为手足综合征、腹泻、血白细胞减少、恶心、呕吐、口腔粘膜炎,但程度均较轻,主要为Ⅰ～Ⅱ度,经对症处理后很快恢复。结论卡培他滨单药治疗晚期胃癌的效果确切,安全有效,可明显改善患者症状,提高患者的生活质量,毒副反应小,患者可以耐受。
Objective To observe the short-term curative effect and toxicity of capecitabine in the treatment of elderly patients with advanced gastric cancer. Methods From December 2006 to December 2009, capecitabine was used to treat 35 cases of elderly patients with advanced gastric cancer. Capecitabine was administered at 2500 mg / m2 orally twice daily for days 1 to 14 and 21 days for 1 Cycle; even after 4 cycles evaluation of efficacy. Results Of the 35 patients, CR0 (0%), PR10 (28.57%), SD13 (37.14%) and PD12 (34.29%). 26 cases related symptoms improved. The main side effects were hand-foot syndrome, diarrhea, leukopenia, nausea, vomiting, oral mucositis, but to a lesser degree, mainly Ⅰ ~ Ⅱ degrees, recovered quickly after symptomatic treatment. Conclusion Capecitabine monotherapy for the treatment of advanced gastric cancer is effective, safe and effective, can significantly improve the symptoms of patients and improve the quality of life of patients with little side effects, patients can tolerate.