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目的：与环孢素（Ｃｉｃ）比较，研究康乐霉素Ｃ（Ｋａｎ）对小鼠免疫系统的影响．方法：皮肤迟发性超敏反应（ＤＨ）和环磷酰胺（Ｃｙｃ）增强型ＤＨ；同种异型皮肤和心脏移植；脾细胞溶血素测定；腹腔巨噬细胞吞噬中性红．结果：Ｋａｎ（１２５，２５，５０ｍｇ·ｋｇ－１·ｄ－１，ｉｇ，８ｄ）与Ｃｉｃ相似，抑制小鼠皮肤ＤＨ和Ｃｙｃ增强型ＤＨ（Ｐ＜００１）；延长小鼠同种异型皮肤和心脏移植物存活时间（Ｐ＜００１）；对溶血素产生也有抑制作用（Ｐ＜００１）；Ｋａｎ５０ｍｇ·ｋｇ－１·ｄ－１，ｉｇ，５ｄ与Ｃｙｃ相似，对小鼠腹腔巨噬细胞吞噬中性红无明显作用（Ｐ＞００５）．结论：Ｋａｎ显著抑制小鼠细胞免疫和体液免疫，但不影响巨噬细胞的吞噬．
OBJECTIVE: To compare the effects of kanamycin C (Kan) on the immune system in mice compared with Cic. Methods: Delayed skin hypersensitivity (DH) and cyclophosphamide (DH) enhanced DH; Allogeneic skin and heart transplantation; Determination of splenic hemolysin; Peritoneal macrophages phagocytose neutral red. Results: Kan (125, 25, 50mg · kg-1 · d-1, ig, 8d) was similar to Cic and inhibited DH and Cyc-enhanced DH in mouse skin (P <001) (P <001), but also hemolysin (P <001). Kan50mg · kg-1 · d-1, ig and 5d were similar to Cyc Mouse peritoneal macrophages phagocytose neutral red no significant effect (P> 0 05). Conclusion: Kan significantly inhibits cellular immunity and humoral immunity in mice, but does not affect macrophage phagocytosis.