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目的:观察雷利度胺治疗难治复发急性粒细胞白血病的疗效及不良反应。方法:给予雷利度胺单药治疗,雷利度胺50mg/d,口服给药,连续给药21天,28天为一个疗程。结果:应用雷利度胺4(2～6)个疗程,5例有效,2例获得完全缓解,2例部分缓解,1例因疾病迅速进展死亡退出试验。不良反应主要为疲乏4例,中性粒细胞减少性发热3例,中粒细胞减少4例,血小板减少1例,贫血1例。结论:应用雷利度胺治疗难治复发白血病有效,不良反应轻微且易于耐受。
Objective: To observe the efficacy and adverse reactions of lenalidomide in the treatment of refractory recurrent acute myeloid leukemia. Methods: The lenalidomide monotherapy, lenalidomide 50mg / d, oral administration, continuous administration of 21 days, 28 days for a course of treatment. Results: With lenalidomide 4 (2 ~ 6) courses, 5 cases were effective, 2 cases achieved complete remission, 2 cases partially relieved, and 1 patient died due to the rapid progression of the disease. The main adverse reactions were 4 cases of fatigue, 3 cases of neutropenic fever, neutropenia in 4 cases, thrombocytopenia in 1 case, anemia in 1 case. Conclusion: The application of lenalidomide in the treatment of refractory relapsed leukemia effective, mild adverse reactions and easy to tolerate.