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目的针对曲美他嗪对急性心肌梗死患者经皮冠状动脉介入治疗(PCI)后心功能、左心室重构的影响以及可能的机制进行探索。方法 80例急性心肌梗死患者,随机分成观察组和对照组,每组40例。对照组按照常规方式治疗,观察组在常规治疗的基础上使用曲美他嗪治疗。对两组患者治疗后心脏指数(CI)、左心室射血分数(LVEF)、每搏输出量(SV)、左心室收缩末期容积指数(LVESVI)、心输血量(CO)等指标进行比较。结果治疗后,观察组CI为(4.87±1.28)min/m~2,LVEF为(0.60±0.04)%,SV为(72.54±3.41)ml,LVESVI为(43.87±2.58)ml/m~2,CO为(5.68±1.47)L/min;对照组CI为(3.45±1.21)min/m~2,LVEF为(0.84±0.02)%,SV为(62.54±3.41)ml,LVESVI为(48.24±1.87)ml/m~2,CO为(4.35±1.22)L/min;观察组患者SV、CI、LVEF、LVESVI、CO指标与对照组比较差异具有统计学意义(P<0.05)。结论急性心肌梗死患者PCI术后使用曲美他嗪,在发挥治疗作用的同时可实现对心肌功能的有效保护,有助于提升患者治疗期生活质量。
Objective To investigate the effect of trimetazidine on cardiac function and left ventricular remodeling in patients with acute myocardial infarction after percutaneous coronary intervention (PCI) and its possible mechanism. Methods 80 patients with acute myocardial infarction were randomly divided into observation group and control group, 40 cases in each group. The control group was treated as usual and the observation group was treated with trimetazidine on a routine basis. The cardiac index (CI), left ventricular ejection fraction (LVEF), stroke volume (SV), left ventricular end-systolic volume index (LVESVI) and cardiac output (CO) were compared between the two groups after treatment. Results After treatment, the CI of the observation group was (4.87 ± 1.28) min / m 2, the LVEF was (0.60 ± 0.04)%, the SV was (72.54 ± 3.41) ml and the LVESVI was (43.87 ± 2.58) ml / CO was (5.68 ± 1.47) L / min in control group, CI was (3.45 ± 1.21) min / m 2 in control group, LVEF was (0.84 ± 0.02)%, SV was (62.54 ± 3.41) ml and LVESVI was (48.24 ± 1.87 (P <0.05). The difference of SV, CI, LVEF, LVESVI, CO in the observation group and the control group was statistically significant (P <0.05). Conclusion The use of trimetazidine after PCI in patients with acute myocardial infarction can exert therapeutic effect while effectively protecting myocardial function and improving the quality of life of patients during treatment.