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氧氟沙星{ofloxacin,化学名为(±)-9-氟-2,3-二氢-3-甲基-10-(4-甲基)-1-哌嗪基)7-氧代-7H-吡啶并[1,2,3-de][1,4]苯并噁嗪--6-羧酸}是喹诺酮的衍生物,在实验动物中证明其常积聚在皮肤黑色素细胞内或周围,一般喹诺酮对黑色素具有高亲和力,从这一发现提示头发中色素(黑色素)与头发中药物的积聚密切相关,所以从头发中分析药物是了解病人用药情况的有效途径。本文研究了氧氟沙星在人头发中的排泄机制。在用氧氟沙星洽疗的4个病人的白发中仅有1人发现氧氟沙星,而4人的黑发中均发现氧氟沙星。进一步分析发现同一人白发中药物
Ofloxacin {chemical name: (±) -9-fluoro-2,3-dihydro-3-methyl-10- (4-methyl) 7H-pyrido [1,2,3-de] [1,4] benzoxazine-6-carboxylic acid} is a quinolone derivative that has been shown to be frequently accumulated in or around melanocytes in experimental animals Quinolone generally has a high affinity for melanin. From this finding, it is suggested that pigment (melanin) in the hair is closely related to drug accumulation in the hair. Therefore, analyzing the drug from the hair is an effective way to understand the patient’s medication. This article studies the excretion mechanism of ofloxacin in human hair. Of the four patients treated with ofloxacin, only one of the white hair found ofloxacin, and four of them found ofloxacin. Further analysis found that the same white hair medicine