六种甲状腺疾病血清纤维连结蛋白的含量

• 作 者: 冯根宝 胡兰萍 王竹兰 吴国梁
• 机 构: 南京军区南京总医院内分泌科实验室,南京军区南京总医院内分泌科实验室,南京军区南京总医院内分泌科实验室,南京军区南京总医院内分泌科实验室,
• 出 处: 天津医药
• 发表日期: 1991年10期
• 关键词: 纤维连结蛋白 甲状腺疾病 单纯性甲状腺肿 火箭免疫电泳法 甲状腺瘤 亚急性甲状腺炎 甲状腺机能减退 甲状腺机能亢进 血管内皮细胞 甲状腺腺瘤

用改良火箭免疫电泳法检测血清 FN,正常人血清 FN 含量为205±55mg/L;甲亢患者治疗前为521±341mg/L,升高非常显著(P<0.01),治疗后为196±62mg/L(P>0.05);甲减患者为142±103mg/L,降低非常显著(P<0.01),单纯性甲状腺肿、桥本氏甲状腺炎、甲状腺瘤、亚急性甲状腺炎患者分别为200±54mg/L、360±300mg/L、271±204mg/L、213±24mg/L(P>0.05)。血清 FN 与血清T_3、T_4呈正相关,提示血清 FN 的合成、分泌和代谢受甲状腺激素的影响;血清 FN 可作为甲亢、甲减疗效参考指标,在疾病的鉴别上也有参考价值。

Serum FN was detected by modified rocket immunoelectrophoresis. The serum FN level was 205 ± 55 mg / L in normal people. The level of FN in patients with hyperthyroidism was 521 ± 341 mg / L before treatment (P <0.01), and 196 ± 62 mg / L (P> 0.05). The incidence of hypothyroidism was 142 ± 103 mg / L, and the reduction was very significant (P <0.01). The patients with simple goiter, Hashimoto’s thyroiditis, thyroid tumor and subacute thyroiditis were 200 ± 54 mg /L, 360 ± 300 mg / L, 271 ± 204 mg / L, 213 ± 24 mg / L (P> 0.05). Serum FN and serum T_3, T_4 was positively correlated, suggesting that serum FN synthesis, secretion and metabolism by thyroid hormone; serum FN can be used as a reference index of hyperthyroidism, hypothyroidism efficacy in the identification of the disease also has reference value.