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AIM:TO clarify the effect of SEN virus (SENV) infection on acombination therapy including interferon alfa (IFN-α) orpegylated-IFN with ribavirin in patients with chronic hepatitisand the effect of a combination therapy on SENV.METHODS:SENV DNA was determined by polymerase chainreaction in serum samples from 95 patients with chronichepatitis C.Quantitative analysis was done for SENV H DNA.RESULTS:Twenty-one (22%) of 95 patients were positivefor SENV DNA.There was no difference in clinical andbiochemical parameters between patients with HCV infectionalone and coinfected patients.The sustained response ratefor HCV clearance after combination therapy did not differbetween patients with SENV (52%) and without SENV(50%,n.s.).SENV DNA was undetectable in 76% of theinitially SENV positive patients at the end of follow-up.SENVH response to combination therapy was significantlycorrelated with SENV DNA level (P=0.05).CONCLUSION:SENV infection had no influence on the HCVsustained response rate to the combination therapy.Response rate of SENV to the combination therapy dependson SENV DNA level.
AIM: TO clarify the effect of SEN virus (SENV) infection on acombination therapy including interferon alfa (IFN-α) orpegylated-IFN with ribavirin in patients with chronic hepatitisand the effect of a combination therapy on SENV. METHODS: SENV DNA was determined by Quantitative chain analysis was performed on serum samples from 95 patients with chronic hepatitis X. Quantitative analysis was done for SENV H DNA.RESULTS: Twenty-one (22%) of 95 patients were positivefor SENV DNA. There was no difference in clinical andbiochemical parameters between patients with HCV infectionalone and coinfected patients. Sustained response rate for HCV clearance after combination therapy did not differ between patients with SENV (52%) and without SENV (50%, ns) .SENV DNA was undetectable in 76% of theinitially SENV positive patients at the end of follow-up.SENVH response to combination therapy was significantlycorrelated with SENV DNA level (P = 0.05) .CONCLUSION: SENV infection had no influence on the HCVsustained response rate to the combination therapy. Response rate of SENV to the combination therapy dependson SENV DNA level.