论文部分内容阅读
报道了10例长期摄取镉的患者的尸检和临床所见。10例患者临床表现有蛋白尿、糖尿、骨痛及由于肾小管病而逐渐引起的肾功能衰竭。尸捡发现慢性镉中毒患者的肾近曲小管上皮细胞萎缩、扁平化及肾小管上皮细胞基底膜轻度增厚等。10例患者均有获得性骨软化症,骨软化症的程度与患者肾小管病变程度相宜,这种骨软化症可能与肾小管的病变有重要关系。
The autopsy and clinical findings of 10 patients with long-term exposure to cadmium were reported. Ten patients had clinical manifestations of proteinuria, diabetes, bone pain and renal failure due to progressive renal failure. Corpse picking found that patients with chronic cadmium poisoning of renal proximal tubule epithelial cells shrink, flattening and mild tubular epithelial basement membrane thickening and so on. All 10 patients had acquired osteomalacia. The degree of osteomalacia was similar to that of patients with tubulointerstitial lesions. This osteomalacia may be related to the pathological changes of renal tubules.