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目的 检测抗高血压药盐酸特拉唑嗪的致突变性。 方法 采用中国仓鼠肺 (ＣＨＬ)细胞体外染色体畸变试验。盐酸特拉唑嗪的最大浓度为ＣＨＬ细胞 5 0 %抑制浓度 ,再依次递减共设 4个给药浓度。同时设溶剂、Ｓ9混合液阴性对照及阳性对照 (丝裂霉素Ｃ)。试验在±Ｓ9混合液条件下
Objective To detect the mutagenicity of anti-hypertensive drug terazosin hydrochloride. Methods Chromosome aberration test of Chinese hamster lung (CHL) cells was performed in vitro. The maximum concentration of terazosin hydrochloride was 50% inhibitory concentration of CHL cells, followed by a total of 4 concentrations. At the same time set the solvent, S9 mixture negative control and positive control (mitomycin C). Test in ± S9 mixture conditions