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8～12个碳链长的饱和烷醇具有抗脂包体病毒(例如单纯疱疹病毒,HSV)作用,当链长超过18个碳时,这种作用便会丧失。但最近发现超过18个碳的饱和烷醇,如正-二十二醇(山萧醇)经适当配方使之能直接与靶细胞接触,则可抑制HSV感染。正-二十二醇对脂包体病毒的专一性似可作为广谱抗病毒剂,对非脂包体病毒无活性。将HSV-1接种于豚鼠的脱毛背部,分别涂以正-二十二醇霜剂或对照赋形剂,测量该部位小疱的数目。在接种病毒后的第56 h(高峰期),未治疗部位平均有129个小疱,用正-二十二醇霜剂治疗部位的抑制小疱数为51％,而赋形剂对照部位无抑制小疱的作用。在第72 h(消退期),未治疗部位平均有33个小疱,而正一二十二醇治疗部位平均有0.5个小疱(抑制99％),对照部位有30个小疱(抑制10％)。
Saturated alkanols of 8 to 12 carbon chain lengths have the effect of anti-liposomes (eg, herpes simplex virus, HSV) and lose this effect when the chain length exceeds 18 carbons. More recently, however, it has been found that saturated alkanols of more than 18 carbons, such as n-docosanol (ShanXiao alcohol), when properly formulated to allow direct contact with target cells, can inhibit HSV infection. The specificity of n-docosanol to the liposomal virus may serve as a broad-spectrum antiviral agent that is inactive against non-lipoprotein viruses. HSV-1 was inoculated on the hairless back of guinea pigs and were coated with n-docetaxel cream or control vehicle, respectively, to measure the number of small blisters. On the 56th h post-inoculation (peak), there were an average of 129 small blisters on untreated sites and 51% on small blisters treated with n-docosanol cream, whereas the vehicle control site had no Inhibit the role of small blisters. At 72 h (regression), there were an average of 33 small blisters on the untreated site and 0.5 small blisters (99% inhibition) on average at the placebo, and 30 small blisters on the control site (inhibition 10 %).