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播散性结缔组织疾病包括进行性全身性硬皮病(P.S.S),被认为是一种多源性自身免疫病。P.S.S.的免疫障碍虽没有全身性红斑狼疮明显,但有人发现在一些P.S.S患者血浆中有DNA的抗体存在。至今,研究P.S.S.患者DNA和RNA水平的文献缺如,而关于人类血浆中核酸的存在还一直是争论的问题。这可归咎于现有测定核酸的方法没有特异性和缺乏敏感性所致。最近已有高度敏感和特异的荧光分光光度法。作者检查了18～52岁,患病时间从1.5～23年的28名P.S.S.患者。其中14例是慢性病程,另14例为亚急性病程。18名病人具有Ⅰ活动度,10名属Ⅱ活动度(根据Gusera′s的分类法)。患有Ⅰ活动度慢性P.S.S.患者,照例给予氨基喹啉药物、抗
Disseminated connective tissue disease, including progressive systemic scleroderma (P.S.S), is considered a multi-source autoimmune disease. P.S.S. immune disorder, although no systemic lupus erythematosus obvious, but it was found in some P.S.S patients with plasma DNA antibodies. To date, there is a paucity of literature to study DNA and RNA levels in patients with P.S.S., and the question of the existence of nucleic acids in human plasma has also been a matter of debate. This can be attributed to the lack of specificity and lack of sensitivity of existing methods for determining nucleic acids. Recently, highly sensitive and specific fluorescence spectrophotometry has been developed. The authors examined 28 P.S.S. patients aged 18-52 and having their disease from 1.5 to 23 years old. Of these, 14 were chronic and the other 14 were subacute. Eighteen patients had I activity and 10 genus II activity (according to Gusera’s classification). Patients with I activity chronic P.S.S. patients, given routine amino-quinoline drugs, anti-