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股骨上端骨折在老年人中是常见的,虽然大多数青年人在遭受同等程度的损伤后能够完全复原,但在老年人中却能导致相当高的死亡率和发病率。损伤反应中与年龄相关的变化是导致这些不利影响的因素。这些变化之一就是血浆皮质醇的浓度,有一种观点认为血浆皮质醇浓度的升高是中枢驱使的皮质醇合成作用增强的结果。用免疫放射计测定法(IRMA)测定老年损伤病人和对照组血样中ACTH浓度,同时测定ACTH前体多肽的浓度。测定下列对照组受试
Fractures of the upper femur are common in the elderly, and although most young people recover fully after being subjected to the same degree of injury, they can cause considerable mortality and morbidity in the elderly. Age-related changes in the injury response are the contributing factors to these adverse effects. One of these changes is the plasma cortisol concentration. There is a perception that an elevated plasma cortisol concentration is a result of a centrally-driven enhancement of cortisol synthesis. ACTH concentrations in blood samples from senile injured patients and controls were measured by immunoradiometric assay (IRMA), and the concentration of ACTH precursor polypeptide was determined. The following control groups were tested