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严重的创伤损害常伴有机体防御反应的抑制,包括抗体反应、白细胞趋向性、迟发型超敏感性和白细胞粘附的变化。在防御机制中,白细胞具有重要作用,它产生超氧化物(O_2~-)及其衍化物,并分泌中性蛋白如丝性蛋白酶(GE)和胶原酶,能调节机体对炎症的防御反应。一些细胞素如肿瘤坏死因子(TNF)和白介素1α(IL-1α),可影响白细胞的活力。为研究创伤后白细胞功能的变化,测定了外伤患者和正常人白细胞中所生成O_2~-的含量和GE活性的动态变化,并观察了TNF、IL-1α及脂多糖(LPS)对
Severe traumatic injury is often accompanied by inhibition of the body’s defense response, including changes in antibody response, leukocyte tropism, delayed hypersensitivity and leukocyte adhesion. In defense mechanisms, leukocytes play an important role in the production of superoxide (O 2 -) and its derivatives, as well as the secretion of neutral proteins such as filamentous proteases (GE) and collagenases, which regulate the body’s defensive response to inflammation. Some cytokines, such as tumor necrosis factor (TNF) and interleukin-1α (IL-1α), can affect leukocyte viability. In order to study the changes of leucocyte function after trauma, the dynamic changes of O 2 ~ - content and GE activity in traumatic patients and normal human leucocytes were measured and the effects of TNF, IL-1α and lipopolysaccharide (LPS) on