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目的评价N-糖基化修饰蛋白gp73的血清水平与肝硬化患者Child-Pugh之间的关系及其可能的临床意义。方法所观察的患者均为2009年1月~2010年10月在北京地坛医院门诊及住院肝硬化患者,所有患者均为HBsAg阳性。观察患者共610例,其中男性患者448例,年龄17~82岁,平均48岁;女性患者162例,年龄18~76岁,平均55岁。入组肝硬化患者的Child-Pugh分级主要依据血清白蛋白、总胆红素、凝血酶原活动度、腹水及肝性脑病评价等5项指标。血清gp73浓度采用ELISA法检测。结果伴随肝功能衰退,血清gp73水平也相应升高。血清gp73水平Child-Pugh为C级的患者(255.78 ng/mL±100.89 ng/mL)显著高于B级(203.30 ng/mL±99.15 ng/mL)和A级的患者(125.28 ng/mL±67.05 ng/mL)。血清gp73与白蛋白之间呈显著负相关(r=-0.52,P<0.0001)。结论 HBV感染肝硬化患者血清gp73水平随肝功能恶化而升高。
Objective To evaluate the relationship between serum levels of N-glycosylation-modified protein gp73 and Child-Pugh in cirrhotic patients and its possible clinical significance. Methods The patients observed were all outpatients and hospitalized patients with liver cirrhosis from January 2009 to October 2010 in Beijing Ditan Hospital. All patients were HBsAg positive. A total of 610 patients were observed, including 448 male patients, aged 17 to 82 years, mean 48 years; 162 female patients, aged 18 to 76 years, mean 55 years. Child-Pugh classification of patients with cirrhosis based on five indicators of serum albumin, total bilirubin, prothrombin activity, ascites and hepatic encephalopathy evaluation. Serum gp73 concentrations were measured by ELISA. Results with the decline of liver function, serum gp73 level also increased accordingly. Patients with serum-gp73 levels of Child-Pugh of grade C (255.78 ng / mL ± 100.89 ng / mL) were significantly higher than those with Grade B (203.30 ng / mL ± 99.15 ng / mL) and Grade A (125.28 ng / mL ± 67.05 ng / mL). There was a significant negative correlation between serum gp73 and albumin (r = -0.52, P <0.0001). Conclusion Serum gp73 levels in patients with HBV-infected liver cirrhosis increase with worsening liver function.