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目的:分析高危型HPV感染诊断CINⅡ-Ⅲ(包含累及腺体)在LEEP刀术后应用人重组干扰素α-2b栓联合保妇康栓治疗的临床效果。方法:我院检测高危型病毒方式-流式荧光检测,检测高危型病毒种类:HPV16.18.31.33.35.39.45.51.52.53.56.58.59.66.68.82型,细胞学采用新柏氏膜式液基细胞学检查;细胞学阳性,高危型病毒检测阳性,阴道镜指导下宫颈活检病理诊断确诊;HPV16.18型阳性,细胞学阴性也常规阴道镜指导下宫颈活检病理诊断;我院2013年6月~2015年6月收治的高危型HPV感染,阴道镜指导宫颈活检病理检查诊断CINⅡ-Ⅲ(包含累及腺体)的患者中选择96例作为本次研究对象,将其分为观察组与对照组,每组48例。两组患者均采取LEEP刀手术治疗,观察组术后用人重组干扰素α-2b栓与保妇康栓联合交替治疗,对照组则未用药物后续治疗,所有患者观察期间要求性生活全过程用避孕套。结果:观察组患者高危型HPV的清除率分别为83.33%、93.75%、96.83%,对照组患者高危型HPV的清除率分别为79.17%、83.33%、87.60%,观察组患者的清除率明显高于对照组,且差异十分明显,具统计学意义(P<0.05);2年观察结果活检结果显示,观察组患者有2例存在高危型HPV持续性感染,宫颈活检CINⅠ1例,对照组患者有6例患者存在HPV持续感染,宫颈活检CINⅠ5例,观察组患者的CIN复发比例低于对照组,且差异明显,具统计学意义(P<0.05)。结论:CINⅡ-Ⅲ(包含累及腺体)LEEP刀手术联合术后用人重组干扰素α-2b栓与保妇康栓阴道交替上药治疗具有较好的临床效果,有效阻断宫颈癌的发生,预防CIN复发,值得推广。
OBJECTIVE: To analyze the clinical effect of high-risk HPV infection in the diagnosis of CINⅡ-Ⅲ (including glands involved) after LEEP knife surgery with recombinant interferon α-2b suppository and Baofukang suppository. Methods: Our hospital detection of high-risk virus - flow fluorescence detection, detection of high-risk type of virus: HPV16.18.31.33.35.39.45.51.52.53.56.58.59.66.68.82 type cytology using the new Parker membrane liquid-based cells Positive cytology, high-risk virus positive, cervical biopsy under the guidance of colposcopy diagnosis of pathological diagnosis; HPV16.18-positive, cytology-negative colposcopy under the guidance of conventional cervical biopsy pathological diagnosis; our hospital in June 2013 ~ In June 2015, 96 cases of high-risk HPV infection and colposcopy-guided cervical biopsy pathological diagnosis of CINⅡ-Ⅲ (including gland involvement) were selected as the study subjects, divided into observation group and control group, 48 cases in each group. Two groups of patients were treated with LEEP knife surgery, the observation group after treatment with recombinant interferon alpha-2b suppositories and Baofukang suppository alternating treatment, the control group did not use drug follow-up treatment, all patients required during the observation of the whole process of sexual life condom. Results: The clearance rates of high-risk HPV in the observation group were 83.33%, 93.75% and 96.83% respectively. The clearance rates of the high-risk HPV in the control group were 79.17%, 83.33% and 87.60% respectively. The clearance rate in the observation group was significantly higher (P <0.05) .2-year observation results Biopsy results showed that there were 2 cases of persistent high-risk HPV infection in the observation group, 1 case of cervical biopsy CINⅠ, and the control group had There were 6 cases of persistent HPV infection, cervical biopsy CIN Ⅰ 5 cases, the observation group patients with CIN recurrence rate was lower than the control group, and the difference was statistically significant (P <0.05). Conclusion: CIN Ⅱ-Ⅲ (including the gland involved) LEEP knife surgery combined with postoperative human recombinant interferon α-2b suppository and Bao-Fukang suppository vaginal replacement therapy has a good clinical effect, effectively blocking the occurrence of cervical cancer, Prevention of CIN recurrence, it is worth promoting.