【摘 要】
：
目的 研究沙库巴曲缬沙坦对急性心肌梗死(AMI)大鼠左心功能及脂蛋白相关磷脂酶A2(Lp-PLA2)表达水平的影响.方法 把大鼠随机分为3组,Sham组、AMI组和VALS组.分别观察3组大鼠的心功能指标,血浆Lp-PLA2、hs-CRP水平,大鼠体重、左心室重量、左室重量指数,心肌组织病理学变化和心肌梗死面积.结果 AMI组LVEDD和LVESD值明显升高,LVEF和LVFS水平降低;VALS组较AMI组得到了明显改善(P<0.05);AMI组Lp-PLA2、hs-CRP水平较Sham组升高(P<0.0
【机 构】
：
徐州医科大学 第一临床医学院,江苏 徐州 221004;滨海县人民医院 心血管内科,江苏 盐城 224500;滨海县人民医院 心血管内科,江苏 盐城 224500;徐州医科大学附属医院 心血管内科,江
论文部分内容阅读
目的 研究沙库巴曲缬沙坦对急性心肌梗死(AMI)大鼠左心功能及脂蛋白相关磷脂酶A2(Lp-PLA2)表达水平的影响.方法 把大鼠随机分为3组,Sham组、AMI组和VALS组.分别观察3组大鼠的心功能指标,血浆Lp-PLA2、hs-CRP水平,大鼠体重、左心室重量、左室重量指数,心肌组织病理学变化和心肌梗死面积.结果 AMI组LVEDD和LVESD值明显升高,LVEF和LVFS水平降低;VALS组较AMI组得到了明显改善(P<0.05);AMI组Lp-PLA2、hs-CRP水平较Sham组升高(P<0.05);与AMI组相比,VALS组Lp-PLA2、hs-CRP水平明显回降(P<0.05);AMI组大鼠的体重、左心室质量和左室质量指数高于Sham组(P<0.05);VALS组以上指标均回降(P<0.05);与Sham组相比,AMI组心肌梗死面积及心肌梗死面积/左心室面积均升高(P<0.05);与AMI组相比,VALS组心肌梗死面积显著减少,心肌梗死面积/左心室面积的百分比也明显降低(P<0.05).结论 沙库巴曲缬沙坦可改善急性心肌梗死大鼠心功能,抑制血浆中炎性因子Lp-PLA2和hs-CRP的水平,对心肌组织起到保护作用.
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