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目的:探讨血清胱抑素C(Cys C)水平与子痫前期孕妇不良妊娠结局的关系。方法:子痫前期孕妇74例(A组)按严重程度分为轻度组(31例)和重度组(43例),于孕中期和孕晚期检测血清Cys C。纳入同期的妊娠期高血压孕妇(B组)和正常孕妇(C组)各100例,比较围产期妊娠结局。结果:A组血压、血肌酐、尿素氮、24h尿蛋白水平均高于B、C组(P<0.05),血白蛋白水平低于B、C组(P<0.05)。A组分娩孕周、胎儿出生体重、Apgar评分均低于B、C组(P<0.05),而早产率、胎儿宫内窘迫率、新生儿窒息率均高于B、C组(P<0.05)。子痫前期重度组Cys-C水平在孕中期和孕晚期均显著高于轻度组(P<0.05);不论是孕中期还是孕晚期,血清Cys-C水平增高的子痫前期孕妇分娩孕周、胎儿出生体重、Apgar评分均显著低于Cys-C正常者(P<0.05),而不良妊娠结局率更高(P<0.05)。结论:血清Cys-C水平与子痫前期严重程度相关,血清Cys-C水平升高的子痫前期易发生不良妊娠结局。
Objective: To investigate the relationship between serum cystatin C (Cys C) levels and adverse pregnancy outcomes in pregnant women with preeclampsia. Methods: Seventy-four pregnant women with preeclampsia (group A) were divided into mild group (31 cases) and severe group (43 cases) according to their severity. Serum Cys C was detected in the second trimester of pregnancy and the third trimester of pregnancy. Included in the same period of pregnancy-induced hypertension in pregnant women (B group) and normal pregnant women (C group) of 100 cases, compared perinatal pregnancy outcomes. Results: The blood pressure, serum creatinine, urea nitrogen and 24 h urinary protein in group A were higher than those in group B and C (P <0.05). The serum albumin level in group A was lower than that in group B and C (P <0.05). The gestational age, fetal birth weight and Apgar score of group A were lower than those of group B and C (P <0.05), while the preterm birth rate, fetal distress rate and neonatal asphyxia rate were higher than those in group B and C ). The levels of Cys-C in severe preeclampsia group were significantly higher than those in mild group (P <0.05) in the second trimester and the third trimester of pregnancy. Pregnant women of preeclampsia with elevated serum Cys-C levels, , Fetal birth weight and Apgar score were significantly lower than those with normal Cys-C (P <0.05), while adverse pregnancy outcomes were higher (P <0.05). Conclusion: Serum Cys-C levels are associated with the severity of preeclampsia, and preeclampsia with elevated serum Cys-C levels is associated with adverse pregnancy outcomes.